Please find below a list of our publications or directly look in pubmed:
Dclk1-expressing tuft cells: Critical modulators of the intestinal niche?
Middelhoff M, Westphalen CB, Hayakawa Y, Yan KS, Gershon MD, Wang TC, Quante M.
Am J Physiol Gastrointest Liver Physiol. 2017 Jul 6
Cut-off optimization for 13C-urea breath test in a community-based trial by mathematic, histology and serology approach.
Li ZX, Huang LL, Liu C, Formichella L, Zhang Y, Wang YM, Zhang L, Ma JL, Liu WD, Ulm K, Wang JX, Zhang L, Bajbouj M, Li M, Vieth M, Quante M, Zhou T, Wang LH, Suchanek S, Soutschek E, Schmid R, Classen M, You WC, Gerhard M, Pan KF.
Sci Rep. 2017 May 18.
Nerve Growth Factor Promotes Gastric Tumorigenesis through Aberrant Cholinergic Signaling.
Hayakawa Y, Sakitani K, Konishi M, Asfaha S, Niikura R, Tomita H, Renz BW, Tailor Y, Macchini M, Middelhoff M, Jiang Z, Tanaka T, Dubeykovskaya ZA, Kim W, Chen X, Urbanska AM, Nagar K, Westphalen CB, Quante M, Lin CS, Gershon MD, Hara A, Zhao CM, Chen D, Worthley DL, Koike K, Wang TC.
Cancer Cell. 2016 Dec 7.
Epithelial Dclk1+ cells are not neural crest derived.
Westphalen CB, Middelhoff M, Quante M, Wang TC.
Stem Cell Investig. 2016 Oct 21.
Goblet Cell Ratio in Combination with Differentiation and Stem Cell Markers in Barrett Esophagus Allow Distinction of Patients with and without Esophageal Adenocarcinoma.
Schellnegger R, Quante A, Rospleszcz S, Schernhammer M, Höhl B, Tobiasch M, Pastula A, Brandtner A, Abrams JA, Strauch K, Schmid RM, Vieth M, Wang TC, Quante M.
Cancer Prev Res (Phila). 2016 Nov 2.
Is it necessary to ascertain intestinal metaplasia with goblet cells for the diagnosis of Barrett Esophagus?
Quante M.
Z Gastroenterol. 2016 Aug;54(8):797-8.
Risk prediction in Barrett's esophagus - aspects of a combination of molecular and epidemiologic biomarkers reflecting alterations of the microenvironment.
Brandtner AK, Quante M.
Scand J Clin Lab Invest Suppl. 2016;245:S63-9.
Functional implication of Dclk1 and Dclk1-expressing cells in cancer.
Westphalen CB, Quante M, Wang TC.
Small GTPases. 2016 Jul 26:1-8.
Gastrin stimulates a cholecystokinin-2-receptor-expressing cardia progenitor cell and promotes progression of Barrett's-like esophagus.
Lee Y, Urbanska AM, Hayakawa Y, Wang H, Au AS, Luna AM, Chang W, Jin G, Bhagat G, Abrams JA, Friedman RA, Varro A, Wang KK, Boyce M, Rustgi AK, Sepulveda AR, Quante M, Wang TC.
Oncotarget. 2016 Jul 18. doi:
Dclk1 Defines Quiescent Pancreatic Progenitors that Promote Injury-Induced Regeneration and Tumorigenesis.
Westphalen CB, Takemoto Y, Tanaka T, Macchini M, Jiang Z, Renz BW, Chen X, Ormanns S, Nagar K, Tailor Y, May R, Cho Y, Asfaha S, Worthley DL, Hayakawa Y, Urbanska AM, Quante M, Reichert M, Broyde J, Subramaniam PS, Remotti H, Su GH, Rustgi AK, Friedman RA, Honig B, Califano A, Houchen CW, Olive KP, Wang TC.
Cell Stem Cell. 2016 Apr 7;18(4):441-55.
Three-Dimensional Gastrointestinal Organoid Culture in Combination with Nerves or Fibroblasts: A Method to Characterize the Gastrointestinal Stem Cell Niche.
Pastuła A, Middelhoff M, Brandtner A, Tobiasch M, Höhl B, Nuber AH, Demir IE, Neupert S, Kollmann P, Mazzuoli-Weber G, Quante M.
Stem Cells Int. 2016;2016:3710836.
Long-lived intestinal tuft cells serve as colon cancer-initiating cells.
Westphalen CB, Asfaha S, Hayakawa Y, Takemoto Y, Lukin DJ, Nuber AH, Brandtner A, Setlik W, Remotti H, Muley A, Chen X, May R, Houchen CW, Fox JG, Gershon MD, Quante M, Wang TC.
J Clin Invest. 2014 Feb 3
The rapid rise in gastroesophageal junction tumors: is inflammation of the gastric cardia the underwater iceberg?
Quante M, Abrams JA, Wang TC
Gastroenterology 2013 Aug 23.
Molecular biomarkers in esophageal, gastric, and colorectal adenocarcinoma
Tänzer M, Liebl M, Quante M
Pharmacol Ther. 2013 Jun 19
Bone marrow cells as precursors of the tumor stroma.
Worthley DL, Si Y, Quante M, Churchill M, Mukherjee S, Wang TC.
Exp Cell Res 2013 March 13
Hypomethylating therapy in an aggressive stroma-rich model of pancreatic carcinoma.
Shakya R, Gonda TA, Quante M, Salas M, Kim S, Brooks J, Hirsch S, Davies J, Cullo A, Olive KP, Szabolcs M, Wang TC, Tycko B, Ludwig T.
Cancer Res. 2012 Nov 29
Barrett Esophagus: What a mouse model can teach us about human disease
Quante M, Abrams JA, Lee Y, Wang TC.
Cell Cycle. 2012 Oct 24;11(23)
Stromal cell-derived factor-1 overexpression induces gastric dysplasia through expansion of stromal myofibroblasts and epithelial progenitors
Wataru Shibata, Hiroshi Ariyama, Christoph Benedikt Westphalen, Daniel L Worthley, Sureshkumar Muthupalani, Samuel Asfaha, Zinaida Dubeykovskaya, Michael Quante, James G Fox, Timothy C Wang
Gut, 2012, Feb 23
Bile acid and inflammation activate gastric cardia stem cells in a mouse model of Barrett-like metaplasia
Michael Quante, Govind Bhagat, Julian Abrams, Frederic Marache, Pamela Good, Michele D. Lee, Yoomi Lee, Richard Friedman, Samuel Asfaha, Zinaida Dubeykovskaya, Umar Mahmood, Jose-Luiz Figueiredo, Jan Kitajewski, Carrie Shawber, Charles Lightdale, Anil Rustgi, Timothy C. Wang
Cancer Cell, 2012, Jan 17
IFN-γ inhibits gastric carcinogenesis by inducing epithelial cell autophagy and T-cell apoptosis
Shui Ping Tu, Michael Quante, Govind Bhagat, Shigeo Takaishi, Guanglin Cui, Xiang Dong Yang, Sureshkumar Muthuplani, Wataru Shibata, James G. Fox, D. Mark Pritchard, Timothy C. Wang
Cancer Research 2011, Apr 21
Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth
Michael Quante, Shuiping Tu, Hiroyuki Tomita, Tamas Gonda, Sophie S. Wang, Shigeo Takashi, Gwang Ho Baik, Wataru Shibata, Bethany DiPrete, Kelly S. Betz, Andrea Varro, Benjamin Tycko, Timothy C. Wang
Cancer Cell, 2011 Feb 15
EGFR-overexpression induces activation of telomerase via PI3K/AKT-mediated phosphorylation and transcriptional regulation through Hif1-alpha in a cellular model of oral-esophageal carcinogenesis
Heeg, Steffen; Hirt, Nina; Thaler, Michaela; Kunert, Heike; Queisser, Angela; Quante, Michael; Goessel, Gitta; von Werder, Alexander; Harder, Jan; Beijersbergen, Roderick; Blum, Hubert; Nakagawa, Hiroshi; Opitz, Oliver
Cancer Science, 2011 Feb
In vivo analysis of mouse gastrin gene regulation in enhanced GFP-BAC transgenic mice
Shigeo Takaishi, Wataru Shibata, Hiroyuki Tomita, Guangchun Jin, Xiangdong Yang, Russell Ericksen, Zinaida Dubeikovskaya, Samuel Asfaha, Michael Quante, Kelly Betz, Arthur Shulkes, Timothy Wang
American J of Pathology, 2011 Feb
Correlation Between Serum Gastrin and Cellular Proliferation in Barrett’s Esophagus
Daniel A. Green, Carrie M. Mlynarczyk, Benjamin J. Vaccaro, Kristina C. Capiak, Michael Quante, Charles J. Lightdale, Julian A. Abrams
Therapeutic Advances in Gastroenterology 2010, Dec 17
TFF2 mRNA transcript expression marks a gland progenitor cell of the gastric oxyntic mucosa
Michael Quante, Frederic Marrache, James R. Goldenring, Timothy C. Wang
Gastroenterology. 2010 Aug 11
Potential carcinogenic effects of cigarette smoke and Swedish moist snuff on pancreas: a study using a transgenic mouse model of chronic pancreatitis.
Song Z, Bhagat G, Quante M, Baik GH, Marrache F, Tu SP, Zhao CM, Chen D, Dannenberg AJ, Wang TC
Lab Invest. 2010 Jan 11.
Stem cells in gastroenterology and hepatology.
Quante M, Wang TC.
Nat Rev Gastroenterol Hepatol. 2009 Nov 3
Inactivating cholecystokinin-2 receptor inhibits progastrin-dependent colonic crypt fission, proliferation, and colorectal cancer in mice.
Jin G, Ramanathan V, Quante M, Baik GH, Yang X, Wang SS, Tu S, Gordon SA, Pritchard DM, Varro A, Shulkes A, Wang TC.
J Clin Invest. 2009 Sep
p53 inhibition of AP1-dependent TFF2 expression induces apoptosis and inhibits cell migration in gastric cancer cells.
Tu SP, Chi AL, Ai W, Takaishi S, Dubeykovskaya Z, Quante M, Fox JG, Wang TC.
Am J Physiol Gastrointest Liver Physiol. 2009 Aug
No functional and transductional significance of specific neuropilin 1 siRNA inhibition in colon carcinoma cell lines lacking VEGF receptor 2.
Quante M, Raskopf E, Stahl S, Vogt A, Sauerbruch T, Schmitz V.
Oncol Rep. 2009 May 21
Inflammation and stem cells in gastrointestinal carcinogenesis.
Quante M, Wang TC.
Physiology (Bethesda). 2008 Dec
Atypical Ormond's disease associated with bile duct stricture mimicking cholangiocarcinoma.
Quante M, Appenrodt B, Randerath S, Wolff M, Fischer HP, Sauerbruch T.
Scand J Gastroenterol. 2009;44(1)
Creating oral squamous cancer cells: a cellular model of oral-esophageal carcinogenesis.
Goessel G, Quante M, Hahn WC, Harada H, Heeg S, Suliman Y, Doebele M, von Werder A, Fulda C, Nakagawa H, Rustgi AK, Blum HE, Opitz OG.
Proc Natl Acad Sci U S A. 2005 Oct 25
Differential transcriptional regulation of human telomerase in a cellular model representing important genetic alterations in esophageal squamous carcinogenesis.
Quante M, Heeg S, von Werder A, Goessel G, Fulda C, Doebele M, Nakagawa H, Beijersbergen R, Blum HE, Opitz OG.
Carcinogenesis. 2005 Nov;26
A mouse model of oral-esophageal carcinogenesis.
Opitz OG, Quante M, von Werder A, Heeg S, Blum HE.
Onkologie. 2005 Jan;28
Middelhoff M, Westphalen CB, Hayakawa Y, Yan KS, Gershon MD, Wang TC, Quante M.
Am J Physiol Gastrointest Liver Physiol. 2017 Jul 6
Cut-off optimization for 13C-urea breath test in a community-based trial by mathematic, histology and serology approach.
Li ZX, Huang LL, Liu C, Formichella L, Zhang Y, Wang YM, Zhang L, Ma JL, Liu WD, Ulm K, Wang JX, Zhang L, Bajbouj M, Li M, Vieth M, Quante M, Zhou T, Wang LH, Suchanek S, Soutschek E, Schmid R, Classen M, You WC, Gerhard M, Pan KF.
Sci Rep. 2017 May 18.
Nerve Growth Factor Promotes Gastric Tumorigenesis through Aberrant Cholinergic Signaling.
Hayakawa Y, Sakitani K, Konishi M, Asfaha S, Niikura R, Tomita H, Renz BW, Tailor Y, Macchini M, Middelhoff M, Jiang Z, Tanaka T, Dubeykovskaya ZA, Kim W, Chen X, Urbanska AM, Nagar K, Westphalen CB, Quante M, Lin CS, Gershon MD, Hara A, Zhao CM, Chen D, Worthley DL, Koike K, Wang TC.
Cancer Cell. 2016 Dec 7.
Epithelial Dclk1+ cells are not neural crest derived.
Westphalen CB, Middelhoff M, Quante M, Wang TC.
Stem Cell Investig. 2016 Oct 21.
Goblet Cell Ratio in Combination with Differentiation and Stem Cell Markers in Barrett Esophagus Allow Distinction of Patients with and without Esophageal Adenocarcinoma.
Schellnegger R, Quante A, Rospleszcz S, Schernhammer M, Höhl B, Tobiasch M, Pastula A, Brandtner A, Abrams JA, Strauch K, Schmid RM, Vieth M, Wang TC, Quante M.
Cancer Prev Res (Phila). 2016 Nov 2.
Is it necessary to ascertain intestinal metaplasia with goblet cells for the diagnosis of Barrett Esophagus?
Quante M.
Z Gastroenterol. 2016 Aug;54(8):797-8.
Risk prediction in Barrett's esophagus - aspects of a combination of molecular and epidemiologic biomarkers reflecting alterations of the microenvironment.
Brandtner AK, Quante M.
Scand J Clin Lab Invest Suppl. 2016;245:S63-9.
Functional implication of Dclk1 and Dclk1-expressing cells in cancer.
Westphalen CB, Quante M, Wang TC.
Small GTPases. 2016 Jul 26:1-8.
Gastrin stimulates a cholecystokinin-2-receptor-expressing cardia progenitor cell and promotes progression of Barrett's-like esophagus.
Lee Y, Urbanska AM, Hayakawa Y, Wang H, Au AS, Luna AM, Chang W, Jin G, Bhagat G, Abrams JA, Friedman RA, Varro A, Wang KK, Boyce M, Rustgi AK, Sepulveda AR, Quante M, Wang TC.
Oncotarget. 2016 Jul 18. doi:
Dclk1 Defines Quiescent Pancreatic Progenitors that Promote Injury-Induced Regeneration and Tumorigenesis.
Westphalen CB, Takemoto Y, Tanaka T, Macchini M, Jiang Z, Renz BW, Chen X, Ormanns S, Nagar K, Tailor Y, May R, Cho Y, Asfaha S, Worthley DL, Hayakawa Y, Urbanska AM, Quante M, Reichert M, Broyde J, Subramaniam PS, Remotti H, Su GH, Rustgi AK, Friedman RA, Honig B, Califano A, Houchen CW, Olive KP, Wang TC.
Cell Stem Cell. 2016 Apr 7;18(4):441-55.
Three-Dimensional Gastrointestinal Organoid Culture in Combination with Nerves or Fibroblasts: A Method to Characterize the Gastrointestinal Stem Cell Niche.
Pastuła A, Middelhoff M, Brandtner A, Tobiasch M, Höhl B, Nuber AH, Demir IE, Neupert S, Kollmann P, Mazzuoli-Weber G, Quante M.
Stem Cells Int. 2016;2016:3710836.
Long-lived intestinal tuft cells serve as colon cancer-initiating cells.
Westphalen CB, Asfaha S, Hayakawa Y, Takemoto Y, Lukin DJ, Nuber AH, Brandtner A, Setlik W, Remotti H, Muley A, Chen X, May R, Houchen CW, Fox JG, Gershon MD, Quante M, Wang TC.
J Clin Invest. 2014 Feb 3
The rapid rise in gastroesophageal junction tumors: is inflammation of the gastric cardia the underwater iceberg?
Quante M, Abrams JA, Wang TC
Gastroenterology 2013 Aug 23.
Molecular biomarkers in esophageal, gastric, and colorectal adenocarcinoma
Tänzer M, Liebl M, Quante M
Pharmacol Ther. 2013 Jun 19
Bone marrow cells as precursors of the tumor stroma.
Worthley DL, Si Y, Quante M, Churchill M, Mukherjee S, Wang TC.
Exp Cell Res 2013 March 13
Hypomethylating therapy in an aggressive stroma-rich model of pancreatic carcinoma.
Shakya R, Gonda TA, Quante M, Salas M, Kim S, Brooks J, Hirsch S, Davies J, Cullo A, Olive KP, Szabolcs M, Wang TC, Tycko B, Ludwig T.
Cancer Res. 2012 Nov 29
Barrett Esophagus: What a mouse model can teach us about human disease
Quante M, Abrams JA, Lee Y, Wang TC.
Cell Cycle. 2012 Oct 24;11(23)
Stromal cell-derived factor-1 overexpression induces gastric dysplasia through expansion of stromal myofibroblasts and epithelial progenitors
Wataru Shibata, Hiroshi Ariyama, Christoph Benedikt Westphalen, Daniel L Worthley, Sureshkumar Muthupalani, Samuel Asfaha, Zinaida Dubeykovskaya, Michael Quante, James G Fox, Timothy C Wang
Gut, 2012, Feb 23
Bile acid and inflammation activate gastric cardia stem cells in a mouse model of Barrett-like metaplasia
Michael Quante, Govind Bhagat, Julian Abrams, Frederic Marache, Pamela Good, Michele D. Lee, Yoomi Lee, Richard Friedman, Samuel Asfaha, Zinaida Dubeykovskaya, Umar Mahmood, Jose-Luiz Figueiredo, Jan Kitajewski, Carrie Shawber, Charles Lightdale, Anil Rustgi, Timothy C. Wang
Cancer Cell, 2012, Jan 17
IFN-γ inhibits gastric carcinogenesis by inducing epithelial cell autophagy and T-cell apoptosis
Shui Ping Tu, Michael Quante, Govind Bhagat, Shigeo Takaishi, Guanglin Cui, Xiang Dong Yang, Sureshkumar Muthuplani, Wataru Shibata, James G. Fox, D. Mark Pritchard, Timothy C. Wang
Cancer Research 2011, Apr 21
Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth
Michael Quante, Shuiping Tu, Hiroyuki Tomita, Tamas Gonda, Sophie S. Wang, Shigeo Takashi, Gwang Ho Baik, Wataru Shibata, Bethany DiPrete, Kelly S. Betz, Andrea Varro, Benjamin Tycko, Timothy C. Wang
Cancer Cell, 2011 Feb 15
EGFR-overexpression induces activation of telomerase via PI3K/AKT-mediated phosphorylation and transcriptional regulation through Hif1-alpha in a cellular model of oral-esophageal carcinogenesis
Heeg, Steffen; Hirt, Nina; Thaler, Michaela; Kunert, Heike; Queisser, Angela; Quante, Michael; Goessel, Gitta; von Werder, Alexander; Harder, Jan; Beijersbergen, Roderick; Blum, Hubert; Nakagawa, Hiroshi; Opitz, Oliver
Cancer Science, 2011 Feb
In vivo analysis of mouse gastrin gene regulation in enhanced GFP-BAC transgenic mice
Shigeo Takaishi, Wataru Shibata, Hiroyuki Tomita, Guangchun Jin, Xiangdong Yang, Russell Ericksen, Zinaida Dubeikovskaya, Samuel Asfaha, Michael Quante, Kelly Betz, Arthur Shulkes, Timothy Wang
American J of Pathology, 2011 Feb
Correlation Between Serum Gastrin and Cellular Proliferation in Barrett’s Esophagus
Daniel A. Green, Carrie M. Mlynarczyk, Benjamin J. Vaccaro, Kristina C. Capiak, Michael Quante, Charles J. Lightdale, Julian A. Abrams
Therapeutic Advances in Gastroenterology 2010, Dec 17
TFF2 mRNA transcript expression marks a gland progenitor cell of the gastric oxyntic mucosa
Michael Quante, Frederic Marrache, James R. Goldenring, Timothy C. Wang
Gastroenterology. 2010 Aug 11
Potential carcinogenic effects of cigarette smoke and Swedish moist snuff on pancreas: a study using a transgenic mouse model of chronic pancreatitis.
Song Z, Bhagat G, Quante M, Baik GH, Marrache F, Tu SP, Zhao CM, Chen D, Dannenberg AJ, Wang TC
Lab Invest. 2010 Jan 11.
Stem cells in gastroenterology and hepatology.
Quante M, Wang TC.
Nat Rev Gastroenterol Hepatol. 2009 Nov 3
Inactivating cholecystokinin-2 receptor inhibits progastrin-dependent colonic crypt fission, proliferation, and colorectal cancer in mice.
Jin G, Ramanathan V, Quante M, Baik GH, Yang X, Wang SS, Tu S, Gordon SA, Pritchard DM, Varro A, Shulkes A, Wang TC.
J Clin Invest. 2009 Sep
p53 inhibition of AP1-dependent TFF2 expression induces apoptosis and inhibits cell migration in gastric cancer cells.
Tu SP, Chi AL, Ai W, Takaishi S, Dubeykovskaya Z, Quante M, Fox JG, Wang TC.
Am J Physiol Gastrointest Liver Physiol. 2009 Aug
No functional and transductional significance of specific neuropilin 1 siRNA inhibition in colon carcinoma cell lines lacking VEGF receptor 2.
Quante M, Raskopf E, Stahl S, Vogt A, Sauerbruch T, Schmitz V.
Oncol Rep. 2009 May 21
Inflammation and stem cells in gastrointestinal carcinogenesis.
Quante M, Wang TC.
Physiology (Bethesda). 2008 Dec
Atypical Ormond's disease associated with bile duct stricture mimicking cholangiocarcinoma.
Quante M, Appenrodt B, Randerath S, Wolff M, Fischer HP, Sauerbruch T.
Scand J Gastroenterol. 2009;44(1)
Creating oral squamous cancer cells: a cellular model of oral-esophageal carcinogenesis.
Goessel G, Quante M, Hahn WC, Harada H, Heeg S, Suliman Y, Doebele M, von Werder A, Fulda C, Nakagawa H, Rustgi AK, Blum HE, Opitz OG.
Proc Natl Acad Sci U S A. 2005 Oct 25
Differential transcriptional regulation of human telomerase in a cellular model representing important genetic alterations in esophageal squamous carcinogenesis.
Quante M, Heeg S, von Werder A, Goessel G, Fulda C, Doebele M, Nakagawa H, Beijersbergen R, Blum HE, Opitz OG.
Carcinogenesis. 2005 Nov;26
A mouse model of oral-esophageal carcinogenesis.
Opitz OG, Quante M, von Werder A, Heeg S, Blum HE.
Onkologie. 2005 Jan;28